2024 college football Week 4 picks against the spread, odds, lines, key trends: Vegas expert reveals picks

Iconic programs take center stage during the Week 4 college football schedule in a pair of new conference matchups. In the Big Ten, new conference member No. 11 USC takes on No. 18 Michigan at 3:30 p.m. ET Saturday on CBS. The latest Week 4 college football odds from SportsLine consensus list the Wolverines as 5-point underdogs after they’ve started the year 0-3 against the spread. In the SEC, it’s No. 6 Tennessee at No. 15 Oklahoma as the Sooners play their first conference game in their new home as 6.5-point underdogs.

The Big 12 also has a marquee matchup with No. 12 Utah traveling to No. 14 Oklahoma State (-2.5) in a battle that could go a long way in determining the conference champion. Before locking in any Week 4 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects.

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 4 and revealed picks for each matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the top college football picks Marshall is recommending for Week 4: He’s taking No. 14 Oklahoma (+6.5) to cover at home against No. 6 Tennessee on Saturday at 7:30 p.m. ET. This has been one of the biggest line movers on the Week 4 slate as Oklahoma was as much as a 5-point favorite in the lookahead lines. It has crossed all the way over to Tennessee -6.5, and Marshall has found some key trends that point to Oklahoma’s favor.

After a slow start at OU, head coach Brent Venables has now covered in seven of the past nine games at home. Tennessee also struggled to get going on the road last year, covering just once in five opportunities. The Vols have dominated thus far, but this is easily their biggest test in terms of opposing talent and being in a hostile environment.

The total, meanwhile, has fallen from 61.5 to 57.5, and Marshall likes the value of the Over since these teams are averaging a combined 97.4 points per game thus far in 2024. See which other picks to make here. 

How to make college football picks for Week 4

Marshall has evaluated every other matchup and he’s found an alarming 11-0 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about in one of the week’s biggest games? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 4 college football odds 

See full Week 4 college football picks, odds, predictions here

Friday, Sept. 20

Stanford at Syracuse (-8.5, 56.5)

Illinois at Nebraska (-7.5, 42.5)

San Jose State at Washington State (-12, 55)

Saturday, Sept. 21

North Carolina State at Clemson (-18.5, 44.5)

Florida at Mississippi State (+6, 58.5)

Marshall at Ohio State (-40, 52.5)

Arkansas at Auburn (-2.5, 56.5)

USC at Michigan (+5, 44)

Utah at Oklahoma State (-2.5, 52.5)

Tennessee at Oklahoma (+6.5, 57.5)

Louisiana-Monroe at Texas (-44.5, 52.5)

Baylor at Colorado (-1.5, 51.5)

Kansas State at BYU (+6.5, 48)