2024 college football Week 6 picks against the spread, odds, lines, trends: Vegas expert reveals picks

The Week 6 college football schedule brings a bit of an expanded look with two games on Thursday and four on Friday, leading into Saturday’s slate. Friday features a pair of ranked teams in action No. 6 Oregon hosts Michigan State and No. 25 UNLV hosts Syracuse. The Week 6 college football odds via SportsLine consensus list the Ducks at -24 and the Rebels at -4.5. 

Notable Week 6 college football lines on Saturday include No. 9 Missouri vs. No. 25 Texas A&M (-1.5), No. 4 Tennessee (+13.5) vs. Arkansas, No. 3 Ohio State (-20.5) vs. Iowa, and in a rematch of last year’s title game, No. 10 Michigan (+3) vs. Washington. Before locking in any Week 6 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Bruce also enters the Week 6 college football schedule on a 17-7 roll (+923) on his official SportsLine college football spread picks. 

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 6 and revealed picks for each matchup. Head here to see every pick.

Top college football predictions for Week 6

One of the top college football picks Marshall is recommending for Week 6: He likes Indiana (-14) to cover against Northwestern, citing the Hoosiers’ remarkable new level of play for first-year head coach Curt Cignetti.

The Hoosiers are rolling early in the season as they’re off to a 6-0 start straight up and a 5-1 start against the spread. They’ve won every game by at least 14 points thus far. Northwestern, meanwhile, has failed to cover in its last three.

Marshall is also backing the Over, which has fallen to 42.5, since four straight Indiana games have cleared the total. See which other picks to make here. 

How to make college football picks for Week 6

Marshall has evaluated every other matchup and he’s found an alarming 23-5 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 6 college football odds 

See full Week 6 college football picks, odds and predictions here.

Thursday, Oct. 3

Texas State at Troy (+15, 58)

Sam Houston State at UTEP (+10.5, 50)

Friday, Oct. 4

Jacksonville State at Kennesaw State (+14, 48.5)

Houston at TCU (-17, 49.5)

Syracuse at UNLV (-4.5, 58)

Michigan State at Oregon (-24, 52.5)

Saturday, Oct. 5

Missouri at Texas A&M (-1.5, 49.5)

UCLA at Penn State (-28.5, 44.5)

Auburn at Georgia (-23.5, 52)

Ole Miss at South Carolina (+9, 51.5)

Iowa at Ohio State (-20.5, 44.5)

Alabama at Vanderbilt (+24, 55)

Clemson at Florida State (+14.5, 47)

Baylor at Iowa State (-13, 46)

USC at Minnesota (+8.5, 52)

Michigan at Washington (-3, 40.5)

Tennessee at Arkansas (+13.5, 60.5)

Miami at California (+11.5, 55)

Texas Tech at Arizona (-5, 62.5)