2024 Week 2 NFL picks, odds, best bets from advanced model: This five-way football parlay pays back 25-1

The Houston Texans began their season with a har-dfought 29-27 win over the Indianapolis Colts. With the other two AFC South teams losing their openers, Houston already has a one-game lead in the division and now they’ll get a chance to prove themselves on a national stage in Week 2. The Texans will host the Bears for Sunday Night Football and C.J. Stroud, last year’s NFL Offensive Rookie of the Year, will battle Bears rookie Caleb Williams, the betting favorite to win that award in 2024. Williams struggled in his debut, which is why Houston is a 6.5-point favorite at home in the latest Week 2 NFL odds via the SportsLine Consensus.

How should you approach that matchup and which Week 2 NFL lines should you target as you put together your Week 2 NFL parlay picks? Before you make any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 2 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 2 NFL picks at SportsLine.

Top Week 2 NFL picks

After simulating every game 10,000 times, the model is high on the Kansas City Chiefs (-6, 48) to cover at home against the Cincinnati Bengals. In four career head-to-head matchups with Patrick Mahomes, Joe Burrow is 3-1 both straight up and against the spread. However, Mahomes and the Chiefs were able to win and cover in the 2023 AFC Championship Game, and then Kansas City covered as 7-point favorites with Burrow out of the lineup in Week 17 last season.

That victory began a stretch of seven consecutive covers that is still going for the Chiefs after a 27-20 win over the Ravens 2.5-point favorites in Week 1. Meanwhile, the Bengals are coming off a disastrous opener against the Patriots, losing as 7.5-point home favorites (the largest in the NFL) and producing only 224 yards of total offense in the process. That’s a big reason why the model has Kansas City covering in nearly 60% of simulations. See which other NFL parlay picks to make here.  

How to make Week 2 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a road team that covers the spread in almost 70% of simulations. You can only see the model’s NFL Week 2 best bets and parlay at SportsLine.  

What are the model’s top Week 2 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on an 184-130 run on top-rated picks, and find out.