2024 Week 3 NFL picks, odds, best bets from advanced model: This five-way football parlay would pay out 25-1

The Rams have started 0-2 and will be without their top two receivers Cooper Kupp (ankle) and Puka Nacua (knee) for multiple weeks. Accordingly, the Rams are 7.5-point underdogs against the 49ers in the latest Week 3 NFL odds, one of the largest NFL Vegas spreads of the season. With Rams quarterback Matthew Stafford limited in reliable pass-catchers, can the Rams score enough points against the 49ers to consider including them in Week 3 NFL parlay picks?

Elsewhere, the Steelers (-2) will meet the Chargers in a battle of 2-0 teams without elite offenses and close NFL Vegas lines are often popular selections for NFL parlays, so do one of these teams show better value for Week 3 NFL parlay bets? Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 3 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 3 NFL picks at SportsLine.

Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Seattle Seahawks (-4.5) cover at home against the Miami Dolphins. The Seahawks are off to a 2-0 start and coming off a 23-20 overtime victory over the New England Patriots on the road. Geno Smith put together an eight-play, 71-yard drive in overtime to put Jason Myers in a position to kick a winning 31-yard field goal in overtime after the Seattle defense forced a three-and-out to the Patriots to start OT.

The Dolphins will play their first of multiple games this season with Tua Tagovailoa, who suffered a concussion on Thursday Night Football. Unfortunately for the Dolphins, they are somewhat used to playing without Tagovailoa, who has a history of head injuries and only played one full year in his five NFL seasons, and they’ll turn to Skylar Thompson in Week 3. Miami failed to score on either of Thompson’s drives last week and the Dolphins averaged just 13.5 points per game in Thompson’s previous two starts. The Seahawks are allowing the second-fewest yards per play, including the fewest yards per pass, this season. Seattle is allowing the second-fewest passing yards per game (128.5) in a tough matchup for Thompson and the Miami offense, leaving the SportsLine model to project Seattle to cover the spread in nearly 60% of simulations. See which other NFL parlay picks to make here.  

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home underdog that covers the spread in well over 60% of simulations, defying oddsmakers everywhere. You can only see the model’s NFL Week 3 best bets and parlay at SportsLine.  

What are the model’s top Week 3 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on an 187-130 run on top-rated picks, and find out.