Monday Night Football odds, line, spread: 49ers vs. Jets picks, predictions by Niners expert who’s 22-5

The San Francisco 49ers have reloaded for another run to a Super Bowl and will kick off their 2024 season with a Monday Night Football matchup against the New York Jets. New York is looking to get back to the Super Bowl for the first time since 1969. The Jets (7-10), third in the AFC East, were 3-2 against NFC opponents in 2023. The 49ers (12-5), who won the NFC West, were 2-3 against the AFC a season ago. 49ers running back Christian McCaffrey is inactive with a calf injury.

Kickoff from Levi’s Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. San Francisco is a 3.5-point favorite in the latest 49ers vs. Jets odds from the SportsLine Consensus, while the over/under for total points scored is 43. Before you make any Jets vs. 49ers bets or predictions, you need to see what proven SportsLine NFL expert Micah Roberts has to say, given his mastery of picks involving the 49ers.

Micah Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. Roberts has a strong read on the pulse of the 49ers. In fact, he is an amazing 22-5 (+1650) on his last 27 against-the-spread picks in games involving San Francisco. Anybody following is way up.

Now, Roberts has locked in on Jets vs. 49ers from every angle and just locked in his picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for 49ers vs. Jets betting:

• 49ers vs. Jets spread: San Francisco -3.5
• 49ers vs. Jets over/under: 43 points
• 49ers vs. Jets money line: San Francisco -204, New York +169
• NYJ: Jets have hit the third-quarter game total under in 12 of their last 17 games (+6.30 units)
• SF: 49ers have hit the first-half money line in 16 of their last 22 games (+6.30 units)
• 49ers vs. Jets: See picks at SportsLine 

Why the 49ers can cover

The 49ers have one of the best collection of playmakers in the league, headlined by wide receiver Deebo Samuel with Christian McCaffrey (calf) out. Samuel is one of the best YAC playmakers in the league and finds different ways to be effective. In 2023, the South Carolina product finished 882 receiving yards, 225 rushing yards, and 12 total touchdowns.

Tight end George Kittle is another highly impactful presence. He buys in 100% as a run blocker while being a reliable playmaker as a pass-catcher. The five-time Pro Bowl selection compiled 65 receptions for 1,020 receiving yards, and six touchdowns last season. That was his third season going over 1,000 receiving yards. He had 10 games in 2023 with at least 60 receiving yards. See which team to back here.

Why the Jets can cover

Although Rodgers missed nearly all of last year due to injury, the former four-time MVP Award winner is just three seasons removed from his last MVP season. The 20-year veteran has passed for 59,055 yards, completing 65.3% of his passes with 475 touchdowns against just 105 interceptions. He has a career rating of 103.6. In his last full season in 2022 for the Packers, he played all 17 games, completing 350 of 542 attempts (64.6%) for 26 touchdowns and 12 interceptions.

Powering the Jets ground attack is third-year running back Breece Hall. In 17 games last season, he helped carry the offensive load, rushing 223 times for 994 yards (4.5 average) and five touchdowns. He also caught 76 passes for 591 yards (7.8 average) and four touchdowns. He had seven explosive run plays of 20 or more yards, including an 83-yarder, as well as seven in the passing game, including a long of 50 yards. See which team to pick here.

How to make Jets vs. 49ers picks

Roberts has analyzed Jets vs. 49ers from every possible angle and while we can tell you he’s leaning Over on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s sharing what it is, and which side to back, only at SportsLine.

Who wins Jets vs. 49ers on Monday Night Football, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Jets vs. 49ers spread to back, all from the expert who is an outstanding 22-5 on picks in games involving San Francisco, and find out.