2024 college football Week 4 picks against the spread, odds, lines, trends: Vegas expert reveals top picks

Young quarterbacks will be in the spotlight as the Week 4 college football schedule arrives. Sophomore Jackson Arnold and No. 15 Oklahoma take on redshirt freshman Nico Iamaleava and No. 6 Tennessee in the marquee matchup on Saturday, with the Week 4 college football odds via SportsLine consensus listing the Vols as 7-point road favorites. Redshirt freshman Arch Manning could get his first career start for top-ranked Texas with Quinn Ewers (oblique) uncertain to play. The Longhorns are massive 44.5-point favorites against UTSA.

Freshman Dylan Raiola and No. 22 Nebraska have a ranked matchup on Friday evening as they take on No. 24 Illinois (+7.5). Which of these Week 4 college football lines should you target? Before locking in any Week 4 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects.

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 4 and revealed picks for each matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the top college football picks Marshall is recommending for Week 4: He’s backing No. 15 Oklahoma (+7) against the spread as the Sooners take on the Vols in Norman at 7:30 p.m. ET on Saturday.

Tennessee is unquestionably hot to open the season as the Vols have covered with more than 20 points to spare in their first three games. However, this is the first true road start for Iamaleava, and it should be against an extremely hostile crowd as the Sooners play their first ever SEC game.

The Vols covered just once on the road last year, while Oklahoma has covered in seven of its last nine at home overall. Marshall is expecting a competitive game and likes getting the full seven points with OU, while also backing the Over (57.5) since these teams are a combined 4-2 to that side of the total thus far in 2024. See which other picks to make here. 

How to make college football picks for Week 4

Marshall has evaluated every other matchup and he’s found an alarming 11-0 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about in one of the week’s biggest games? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 4 college football odds 

See full Week 4 college football picks, odds, predictions here

Thursday, Sept. 19

South Alabama at Appalachian State (-7.5, 64.5)

Friday, Sept. 20

Stanford at Syracuse (-9, 57.5)

Illinois at Nebraska (-8.5, 43)

San Jose State at Washington State (-11.5, 55.5)

Saturday, Sept. 21

North Carolina State at Clemson (-20.5, 46.5)

Florida at Mississippi State (+6, 58.5)

Marshall at Ohio State (-39.5, 52.5)

Arkansas at Auburn (-3, 58)

USC at Michigan (+6, 46.5)

Utah at Oklahoma State (+2.5, 54)

Tennessee at Oklahoma (+7, 57.5)

Louisiana-Monroe at Texas (-44, 52.5)

Baylor at Colorado (-1.5, 53.5)

Kansas State at BYU (+7, 47.5)