2024 Week 3 NFL picks, odds, best bets from advanced model: This 5-way football parlay would pay out 25-1

NFL injuries often come in waves, and a colossal wave hit the league last week. Several star players went down, but perhaps no game on the Week 3 NFL schedule is affected by injuries as much as 49ers vs. Rams. San Francisco is a 6.5-point favorite after originally opening at 4.5. The Rams’ injuries to Cooper Kupp, Puka Nacua and three offensive linemen weigh more than Niners’ injuries to Christian McCaffrey and Deebo Samuel. The total for this contest has had an even more dramatic shift from 49 to 44.5, but you can combine NFL against the spread picks and NFL over/under bets into Week 3 NFL parlay picks.

The Week 3 NFL spreads and over/unders could continue to shift, so it may be wise to jump on these NFL lines as soon as possible. Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 3 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 3 NFL picks at SportsLine.

Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Seattle Seahawks (-4.5, 41.5) cover at home against the Miami Dolphins. Seattle is the lone NFC West team above .500 at 2-0, and Miami has simply been non-competitive versus winning teams recently. Over the Dolphins last 13 games against teams .500 or better, they are 2-11 both straight-up and against the spread. Their average margin of defeat is 12.4 points, despite the average closing spread being Miami (+0.4).

Additionally, Miami has lost its last five games overall against the spread, and all of those came with Tua Tagovailoa under center. There’s a massive dropoff from the 2023 passing leader to the undrafted Skylar Thompson, and the model acknowledges that. It has Thompson completing under 60% of his passes with the same number of interceptions as touchdowns. That will be too much for Miami to overcome in a hostile road environment as Seattle is projected to cover well over 50% of the time. See which other NFL parlay picks to make here.  

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home underdog that covers the spread in well over 60% of simulations, defying oddsmakers everywhere. You can only see the model’s NFL Week 3 best bets and parlay at SportsLine.  

What are the model’s top Week 3 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on an 187-130 run on top-rated picks, and find out.