Data Skrive
Having lost three in a row, the San Francisco 49ers (6-10) will take on the Arizona Cardinals (7-9). The Cardinals are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The expected point total for the game is 42.5.
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| Favorite | Spread | Favorite Spread Odds | Underdog Spread Odds | Total | Over Total Odds | Under Total Odds |
|---|---|---|---|---|---|---|
| Cardinals | -4.5 | -110 | -110 | 42.5 | -110 | -110 |
Cardinals vs. 49ers Prediction & Pick
- Pick ATS: Cardinals (-4.5)
- Pick OU: Over (42.5)
- Prediction:
Cardinals 26 – 49ers 20
How to Watch Arizona vs. San Francisco
- Game Date: Sunday, January 5, 2025
- Time: 4:25 p.m. ET
- Venue: State Farm Stadium
- Location: Glendale, Arizona
- TV: Watch on FOX
- Live Boxscore: FOX Sports
Read More NFL Predictions For This Week
Cardinals vs. 49ers Recent Matchups
- San Francisco has a 4-1 record against Arizona in their last five matchups.
- In their last five head-to-head matchups, San Francisco has scored 179 points against Arizona, while surrendering only 92 points.
Arizona Betting Info
- Arizona has played 16 games, posting 10 wins against the spread.
- The Cardinals have covered the spread once when favored by 4.5 points or more this season (in two opportunities).
- Arizona games this year have gone over the total in seven out of 16 opportunities (43.8%).
- When playing as moneyline favorites, the Cardinals are 2-4 (winning 33.3% of the time).
- The Cardinals have a 68.6% chance to win this matchup, based on the implied probability of the moneyline.
Cardinals Stats
| Stat | Average (Total) | Rank |
|---|---|---|
| Pass yards | 212.3 (3,397) | 18 |
| Rush yards | 143.8 (2,300) | 7 |
| Points scored | 22.1 (353) | 15 |
| Pass yards against | 211.0 (3,376) | 12 |
| Rush yards against | 125.7 (2,011) | 20 |
| Points allowed | 22.2 (355) | 14 |
Arizona’s Key Players
Offense
- Kyler Murray has thrown for 3,609 yards, 17 touchdowns and 11 interceptions this year. He is averaging 225.6 yards per game and 7.1 per attempt, while completing 68.6% of his attempts.
- He has added 550 rushing yards (34.4 per game) and five touchdowns on the ground.
- Marvin Harrison Jr.’s 822 receiving yards this season have come from 110 targets and 57 receptions. He’s averaging 51.4 receiving yards and 3.6 catches per game, with seven receiving touchdowns.
- Trey McBride has one touchdown catch this season, and has 104 catches (fourth in the NFL) for 1,081 yards on 136 targets, while averaging 6.9 catches and 72.1 yards per game.
- Michael Wilson averages 2.9 receptions and 34.3 yards per game, and has 548 total receiving yards and 47 catches. He’s gotten 71 total targets, and has caught four touchdown passes.
Defense
- On the defensive side, Budda Baker has 154 tackles, 9.0 TFL, two sacks, and five passes defended in 2024.
- Kyzir White has 127 tackles, 8.0 TFL, 2.5 sacks, and one interception this season. He’s second on the Cardinals in tackles.
- Mack Wilson has totaled one interception and has added 73 tackles, 4.0 TFL, three sacks, and four passes defended.
- This season, Jalen Thompson has 88 tackles and 2.0 TFL.
San Francisco Betting Info
- San Francisco is 5-11-0 against the spread this season.
- The 49ers have yet to cover the spread this season when underdogs by 4.5 points or more in three chances.
- Games involving San Francisco have hit the over on nine occasions this season.
- This season, the 49ers have been listed as the underdog in three games and failed to win any of those contests.
- The 49ers have a 35.7% chance to win this game based on the implied probability of the moneyline.
49ers Stats
| Stat | Average (Total) | Rank |
|---|---|---|
| Pass yards | 246.0 (3,936) | 4 |
| Rush yards | 126.6 (2,025) | 11 |
| Points scored | 22.8 (365) | 13 |
| Pass yards against | 189.8 (3,036) | 4 |
| Rush yards against | 122.9 (1,967) | 17 |
| Points allowed | 24.3 (389) | 22 |
San Francisco’s Key Players
Offense
- Brock Purdy is averaging 8.5 passing yards per attempt (third in the NFL) and 257.6 yards per game this year, completing 65.9% of his passes on the way to 3,864 total yards (eighth in the NFL), 20 touchdowns and 12 interceptions through 15 games.
- Purdy has also rushed for five touchdowns and 323 yards (third on the 49ers).
- George Kittle has 76 catches for 1,079 yards and eight receiving touchdowns. He has been targeted 91 times and averages 5.4 receptions per game through 14 games played.
- In 14 games played this season, Jauan Jennings has 70 catches (5.0 receptions per game on 7.4 targets per game) for 923 yards and six receiving touchdowns.
- Deebo Samuel has been targeted 81 times, resulting in 51 catches for 670 yards .
Defense
- Fred Warner has amassed 1.0 sack to go with 4.0 TFL, 123 tackles, and two interceptions through 16 games in 2024.
- Nick Bosa’s stat sheet includes one interception as well as 52 tackles, 15.0 TFL, nine sacks, and one pass defended.
- Deommodore Lenoir has 2.0 TFL, 85 tackles, and two interceptions in the 2024 season.
- Leonard Floyd has put up 8.5 sacks (second on the 49ers) to go with 8.0 TFL and 39 tackles through 13 games.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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Arizona Cardinals
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