College football odds, picks, bets, predictions for Week 7, 2024: Computer model likes Notre Dame, Vanderbilt

The Week 7 college football schedule looks like one of the best of the year, with high-profile rivalry games like Texas vs. Oklahoma and critical top-25 matchups like Ohio State vs. Oregon and Ole Miss vs. LSU. The Buckeyes are ranked No. 2 in the AP Top 25 while the Oregon Ducks are ranked No. 3, and the winner of Saturday’s matchup in Eugene could have the inside track on winning the Big Ten championship. The latest Week 7 college football odds list Ohio State as the 3.5-point favorite while the over/under is at 52.5 points.

Meanwhile, No. 1 Texas is a 14.5-point favorite over No. 18 Oklahoma while No. 9 Ole Miss is a 3.5-point favorite over No. 13 LSU in the Week 7 college football lines. So how should you be handling those matchups, and what other Week 7 college football spreads can you capitalize on this weekend? Before locking in any Week 7 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is 8-4 on top-rated picks over the past two weeks of this season. Anyone who has followed it has seen strong returns. 

Now, it has turned its attention to the latest college football odds and Week 7 college football betting lines on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 7 

One of the college picks the model is high on during Week 7: No. 11 Notre Dame (-23.5) cruises to a blowout win over Stanford in a 3:30 p.m. ET matchup on Saturday. Notre Dame was the significantly better side when these teams met last season, covering the spread as a 26-point road favorite in a 56-23 win. The Fighting Irish have won 10 of their last 12 home games, and they have covered the spread in six of their last eight games overall.

Stanford has struggled dating back to the end of last season, covering just twice in its last eight games. Additionally, the Cardinal have been consistently bad away from home, going 5-11 against the spread in their last 16 road games. SportsLine’s model expects those trends to continue on Saturday, as Notre Dame is scoring more than 40 points and covering the spread in nearly 60% of the latest simulations. See the rest of its Week 7 college football picks here. 

Another prediction: Vanderbuilt covers as 13.5-point road underdogs against Kentucky in a 7:45 p.m. ET kickoff on Saturday. The Commodores are coming off their biggest win in program history, knocking off No. 1 Alabama as 22.5-point home underdogs. The win improved Clark Lea’s program to 3-2 and gave Vanderbilt its first win over an AP Top 5 program in school history.

New Mexico State transfer Diego Pavia went 16-for-20 for 252 yards and two touchdowns without an interception while also rushing for 56 yards in the victory. Pavia has thrown for eight touchdowns without an interception so far this season and has also rushed for 335 yards and two touchdowns. Vanderbilt also won the turnover battle 2-0 against Alabama and that’s a big reason why the model has the Commodores covering in over 60% of simulations. See picks for every other game in Week 7 here. 

How to make college football picks for Week 7

The model has also made the call on who wins and covers in every FBS matchup in Week 7, and it’s calling for a whopping 10 underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which 10 underdogs win outright in Week 7? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.

College football odds for Week 7

See full Week 7 college football picks, odds, predictions here

Wednesday, Oct. 9

New Mexico State at Jacksonville State (-20.5, 59)

Thursday, Oct. 10

Coastal Carolina at James Madison (-9.5, 61)

Middle Tennessee at Louisiana Tech (-4.5, 49)

UTEP at Western Kentucky (-19.5, 57.5)

Friday, Oct. 11

Northwestern at Maryland (-10, 45.5)

UNLV at Utah State (+19, 65.5)

Utah at Arizona State (+6.5, 45.5)

Saturday, Oct. 12

Clemson at Wake Forest (+20, 60.5)

South Carolina at Alabama (-21.5, 50.5)

Stanford at Notre Dame (-23.5, 45.5)

Texas vs. Oklahoma (+14.5, 50.5)

Penn State at USC (+5.5, 51)

Mississippi State at Georgia (-33.5, 53.5)

Florida at Tennessee (-15.5, 55.5)

Ole Miss at LSU (+3.5, 64)

Ohio State at Oregon (+3.5, 53.5)

Iowa State at West Virginia (+3, 53)

Kansas State at Colorado (+4, 56.5)