College football odds, picks, lines, bets, predictions for Week 6, 2024: Computer model likes Iowa, California

No. 7 Penn State has a huge game looming against No. 11 USC next week, but it will first be looking to take care of business against UCLA on Saturday during the Week 6 college football schedule. The Nittany Lions have won their first four games this season, including a 21-7 win over then-No. 19 Illinois last week. They are 28-point favorites against UCLA in the Week 6 college football odds as they wrap up a four-game homestand. The Bruins are coming off three straight blowout losses, so should you back Penn State with your Week 6 college football bets?

Meanwhile, top-ranked Alabama (-22.5) heads to Vanderbilt, No. 3 Ohio State (-18.5) hosts Iowa and No. 5 Georgia (-22.5) faces Auburn. There are also some small Week 6 college football spreads, including No. 9 Missouri (+2.5) at Texas A&M and No. 10 Michigan (+1.5) at Washington. Before locking in any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks. It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns. 

Now, it has turned its attention to the latest college football odds and Week 6 college football betting lines on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 6 

One of the college picks the model is high on during Week 6: Iowa (+18.5) stays within the big spread at No. 3 Ohio State in a 3:30 p.m. ET matchup Saturday on CBS. The Buckeyes failed to cover the spread in their final two games last season, and they have not covered in two of their first four games this season. They have a huge game looming at No. 6 Oregon next week, making this a trap game on their schedule following their win at Michigan State last week. 

Iowa can lull Ohio State to sleep on Saturday, as the Hawkeyes have one of the best rushing attacks in college football. Junior running back Kaleb Johnson has rushed for 685 yards and nine touchdowns in his first four games, averaging a whopping 8.4 yards per carry. The Hawkeyes also rank inside the top 20 in total defense, so SportsLine’s model has them covering the spread well over 50% of the time. See the rest of its Week 6 college football picks here. 

Another prediction: California (+10.5) plays a one-score game against No. 8 Miami in a 10:30 p.m. ET kickoff on Saturday. California has been an elite defensive team early in the season, ranked No. 12 in college football in points allowed per game (12.8). The Golden Bears have not allowed more than 14 points in any of their first four games, so they will provide a new test for Miami quarterback Cameron Ward.

On the other side of the ball, Cal’s offense is facing a Hurricanes defense that gave up 34 points in a narrow win over Virginia Tech last week. Sophomore running back Jaivian Thomas has rushed for 267 yards on 38 carries, averaging 7.0 yards per attempt. The Golden Bears are 5-2 in their last seven home games, while Miami has only covered the spread four times in their last 17 conference games, so the model has California covering in nearly 60% of simulations. See picks for every other game in Week 6 here. 

How to make college football picks for Week 6

The model has also made the call on who wins and covers in every FBS matchup in Week 6, and it’s calling for a whopping seven underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which seven underdogs win outright in Week 6? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.

College football odds for Week 6

See full Week 6 college football picks, odds, predictions here

Friday, Oct. 4

Jacksonville State at Kennesaw State (+16.5, 48.5)

Houston at TCU (-17, 51.5)

Syracuse at UNLV (-6.5, 57)

Michigan State at Oregon (-23.5, 52.5)

Saturday, Oct. 5

Missouri at Texas A&M (-2.5, 48.5)

UCLA at Penn State (-28, 46.5)

Auburn at Georgia (-22.5, 51.5)

Ole Miss at South Carolina (+8, 53.5)

Iowa at Ohio State (-18.5, 45.5)

Alabama at Vanderbilt (+22.5, 54.5)

Clemson at Florida State (+14.5, 46.5)

Tennessee at Arkansas (+13.5, 57.5)

Baylor at Iowa State (-12.5, 45)

USC at Minnesota (+8.5, 49.5)

Michigan at Washington (-1.5, 41.5)

Miami at California (+10.5, 54)

Texas Tech at Arizona (-6.5, 64)