George Lopez is retiring from stand-up — what could be his last project?

George Lopez is stepping down from stand-up. The comedian opened up about his major career change during an interview with Tamron Hall.

“It is the last one,” he said of his upcoming special for Amazon’s Prime Video. “I’ve subjected the American people to enough of my crap. It seems like the right time; it’s been the one thing that has just never left me my whole life and it’s a wonderful place to leave it at this particular point.”

In part, Lopez also wants to spend more time with his daughter Mayan Lopez. The pair share the screen in their NBC comedy “Lopez vs Lopez,” which is headed into its third season.

“I love the show,” he went on.

The actor, 63, told People on Wednesday that the sitcom will be his final project.

“It makes it happy. I mean, I would like for it to go a few more seasons, but yeah, after this, I’d like to have a little time for myself,” he said while attending NBC’s Comedies celebration with Mayan, 28.

He went on to discuss his working dynamic with Mayan and her work ethic.

“In the beginning, I could tell when she was a little bit maybe frustrated a little bit and I would talk to her a little bit, but she works really hard when she’s not on the set,” he explained. “That’s my big thing — is to be on time. And she’s always prepared.”

“It’s exciting,” he continued. “I mean, every week that we do the show, she just gets better and better. She’s able to do more physical stuff, more character stuff, and that’s really kind of what she talked about when she was 12 and she was talking about wanting to be on TV.”

Mayan chimed in: “It’s like working with your parent, but I have so much fun with him always.”

His career news comes months after he slammed an “inadequate” casino for what he described as an “unsafe environment.”

Eagle Mountain Casino alleged that the comedian walked out of his show 30 minutes before it was scheduled to end and blamed his security team who could’ve “easily escorted any hecklers out.”

The casino said that Lopez “let down his fans and sold out audience” by leaving early.

His rep later released a statement to The Post about the situation.

“It’s the venue or casino’s job to provide a good experience for both the artist and the fans, but the casino failed in this regard,” a spokesperson for George said at the time.

“The audience was overserved and unruly, and the casino staff was unable to provide a safe and enjoyable experience for the artist and guests. George’s personal security team worked with the venue security staff to maintain order, ensure safety, and eject disruptive individuals,” the statement continued. “Unfortunately, the casino security team was not adequate to accomplish this task. George is not obligated to perform in an unsafe environment. He feels badly that those who came to see the show were unable to do so as a result.”