Self-learning AI gives NFL against the spread, over-under, money-line picks for each 2024 Week 2 game

Evaluating season-opening performances can be difficult since wins often have more to do with the opponent than any other factor. New Orleans scored a league-high 47 points in its blowout win over Carolina, which is expected to be one of the worst teams in the NFL. The Saints are six-point underdogs against the Cowboys in the Week 2 NFL odds, so should you back the Cowboys with your Week 2 NFL bets and NFL score predictions?

The Cowboys are one of eight teams favored by at least six in the Week 2 NFL spreads, with the Ravens listed as the heaviest favorites at -8.5 against the Raiders. This week’s slate concludes with a matchup between the Eagles (-6.5) and Falcons on Monday Night Football. Before you make any Week 2 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 2, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 2 NFL schedule here.

Top Week 2 NFL AI picks

After analyzing every game in Week 2, the AI PickBot says the Jaguars cover as three-point favorites at home against the Browns. Cleveland’s offense looks like it might need to pivot to a new starting quarterback at some point this season, as Deshaun Watson continues to disappoint the fan base. He threw two interceptions and was sacked a league-high six times in a 33-17 loss to Dallas last week, and the Browns went just 2 of 15 on third down.

Jacksonville nearly took a 24-7 lead late in the third quarter against Miami in Week 1, but running back Travis Etienne fumbled near the goal line and the Dolphins stormed back to win. However, rookie wide receiver Brian Thomas Jr. had four catches for 47 yards and a touchdown in his debut, while Gabe Davis had three receptions for 62 yards. They are facing a Cleveland defense that will be without starting safety Juan Thornhill, which is one reason why the AI PickBot has Jacksonville winning by around five points, on average. See its other Week 2 football predictions and football picks at SportsLine.

How to make Week 2 NFL picks

In addition, the AI PickBot has generated five A-rated picks for Week 2. You need to see the AI PickBot’s picks before making any Week 1 NFL bets of your own. You can only see it at SportsLine.

Who wins and covers each Week 2 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.