Self-learning AI gives NFL against the spread, over-under, money-line picks for every Week 5, 2024 game

The Denver Broncos have found a way to win their last two games, putting them back at .500 heading into their game against the Raiders during the Week 5 NFL schedule. Rookie quarterback Bo Nix finished with just 60 passing yards on 25 attempts last week, but he threw his first NFL touchdown in a 10-9 win over the Jets. The Broncos are three-point home favorites against the Raiders in the Week 5 NFL odds after the line opened at 1.5, as Las Vegas looks to build on a 20-16 win over Cleveland. There are five other divisional games this week, but which ones should you target with your Week 5 NFL best bets and Week 5 NFL score predictions?

This week’s slate concludes when Kansas City (-5.5, 43) hosts New Orleans on Monday Night Football, as the Chiefs try to stay unbeaten. The only other undefeated team in the league is Minnesota, which is a 2.5-point favorite against the Jets in London on Sunday in a game with an over-under of 40.5, down a field goal from the opener. Before you make any Week 5 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has nailed 128 4-star picks or better this season and hit a whopping 1,674 4.5- and 5-star prop picks last season. Anyone who has followed it is way up.

For Week 5 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 14 games. You can only see the AI predictions for the Week 5 NFL schedule here.

Top Week 5 NFL AI picks

After analyzing every game in Week 5, the AI PickBot says the Cardinals cover as 7.5-point road underdogs against the division-rival 49ers in a game with an over-under of 49.5. Arizona is getting set for its second road game of the season following a 42-14 blowout loss to Washington last week. The Cardinals were 6.5-point underdogs at Buffalo in their first road game of the campaign, covering the spread in a 34-28 loss in Week 1. 

They cruised to a blowout win over the Rams before playing a close game against the Lions, so it has been a bit of a sporadic start for Arizona this season. San Francisco is coming off a win over New England, but it has only covered the spread twice in its last eight games. The AI PickBot is fading the 49ers again this week, projecting Arizona to lose by just three points on average. See its other Week 5 football predictions and football picks at SportsLine.

How to make Week 5 NFL picks

In addition, the AI PickBot has generated two A-rated picks for Week 5, including a coveted A+ pick. You need to see the AI PickBot’s NFL picks before making any Week 5 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 5 NFL game, and which A+ pick should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 128 top-rated picks this season.