Self-learning AI says NFL against the spread, over-under, money-line picks for every 2024 Week 1 game

The 2024 NFL schedule is finally here and the bulk of the action in Week 1 will take place on Sunday, where there will be eight games in the early window, four games in the late window and a marquee matchup on Sunday Night Football. Lions vs. Rams is a rematch of an NFC wild card game last season and Detroit pulled off a 24-23 win in that contest. Aaron Donald’s retirement leaves Los Angeles missing its anchor in the middle of the defense and the Lions’ offense will look to capitalize. The Lions are favored by 3.5 in the Week 1 NFL odds, but what game script should you expect and how can you make sure you’re in the neighborhood with all your Week 1 NFL score predictions? Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.

Top Week 1 NFL AI picks

After analyzing every game in Week 1, the AI PickBot says the Broncos cover as six-point underdogs against the Seahawks in a game that has earned an A-rated pick. After back-to-back 9-8 seasons, the Seahawks and Pete Carroll agreed to mutually part ways this offseason after 14 years together. Seattle hired Ravens defensive coordinator Mike Macdonald in his place, and he’s one of the best defensive signal-callers in the game but this is his first head coaching role.

He’ll have to match wits with Sean Payton, a veteran with 17 years of head coaching experience who improved the Broncos from 5-12 to 8-9 in his first season at the helm. Denver’s bend-but-don’t-break mentality defensively helped them stay competitive, with the Broncos ranking second in the NFL in defensive third-down conversion rate (33.2%). The model expects that ability to get off the field to help Denver keep this close, with Seattle winning 21.86-20.34 on average and the Broncos covering comfortably. See its other Week 1 football predictions and football picks at SportsLine.

How to make Week 1 NFL picks

In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot’s analysis before making any Week 1 NFL bets. You can only see it at SportsLine.

Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.